JFK's sister getting a lobotomy, and then being promptly institutionalized and hidden away from the family for the rest of her life.
It was truly a sad tragedy, and shows how differently we view mental disabilities today. Rosemary was functioning but slow, but she had violent outbursts and got rebellious once she hit puberty. They were so afraid she would get pregnant and shame the Kennedy family name, they elected to get her a lobotomy (a new treatment at the time). It messed her up badly. She couldn't walk or talk, and needed constant care for the rest of her life.