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Honestly guys.... I dont think I'd use a reboot with a new cast. I think what was so iconic about the show was that we've NEVER seen a show that went that far and was so controversial, especially a teen drama... I think in this day in age, we've kinda seen it all now. It would be kinda late... Overdosing on coke in hotel rooms, blackmailing sex tapes, and sleeping with the dean is kinda old news now to this new generation.
Idk.... if done right and with perfect casting, it could book. I'd like to see Georgina on the show from the START. Her, Blair, and Serena battling for queen of Constance! That would be a different and interesting twist.